the literature review reveals domain B do exist as general, common and independent proteins and are conserved but domain A is characteristic to protien they form but cant function alone as they need B. during evolution these domains corresponding genes fused together to give rise a new class of proteins (as it is supposed). which form of bioinformatics analysis can help in ascertaining the evolution and making of above mentioned protein?
If you do an English spelling and grammar check, your question will be easier to read and more likely to be answered. It's such hard work to understand it as it is! Even though English may not be your first language, you at least need to capitalise the first word of every sentence :)
Thanks Andrew for your reply. In simple words i want to ask if there is insertion of one protein domain into another. Does that reflects also there is fusion of their corresponding genes？ If that is the case how to check gene fusion and validate it
Genes that code for different proteins can certainly join together to form fusion or chimeric proteins.