Can anyone tell me how to synthesize this molecule?
1-(4-amino-2,6-diphenylpyrimidin-5-yl)ethanone. Is it available in Scifinder?
Dear all, I have some compounds which good activity against some cancer cell lines (such as DU145 (Human prostate Cancer), MDA MB-231 (human breast cancer), etc. Now I want to search for the...
31 December 2018 8,212 7 View
I developed a device for cutting the TLC plates. This is my new invention and this design is registered. I wish to commercialize this product. Please let me know if it is useful for daily...
02 March 2018 7,362 15 View
Contract Research Organizations are growing very fast and drug discovery programs are exclusively using these services. However, I think that this culture is not able to produce the drug flow as...
31 December 2017 673 4 View
Rf values (TLC and HPLC) are used to identify the drug molecules. However this information can be of great value in medicinal chemistry and drug discovery. I think there's a great correction...
11 December 2017 6,875 12 View
Rapidly changing pharmaceutical R&D strategies put medicinal chemists in big trouble. Big pharmaceuticals now a days are solely depend on CRO industry for their discovery projects. In my view...
07 August 2016 5,980 4 View
Hi all, Now a days boronate chemistry is done routinely by most of the chemists. I am synthesizing boronates in my lab. We generally do not purify the boronates (only filter the reaction mixture...
06 July 2016 7,288 5 View
Dear all, I want to convert an ester to nitrile in one step. My structure contains base labile groups so I cannot use ester amine procedures. Is there any method through which I can easily convert...
31 December 2015 4,031 20 View
Reviews play a pivotal part in present day research. However, patent searching is a tedious job. I want to write a review on anti-diabetic compounds. I want to add patented anti-diabetic compounds...
04 May 2014 3,903 6 View
Reviews play a pivotal part in present day research. However, updated reviews take a lot of efforts to design. I want to write a review on anti-diabetic compounds which are currently progressing...
04 May 2014 8,800 5 View
We have isolated β -Glucuronidase (cleaves β-glycosidic bond) enzyme from E. coli and two other species. These enzymes were then tested for their glucuronidase activity on Glycyrrhizin (structure...
09 October 2013 9,171 9 View
I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...
08 August 2024 8,329 0 View
I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...
30 July 2024 6,420 1 View
Dear Siesta Users, I installed Siesta 5.0.1 and I want to use Grimme's D3 correction. According to the 5.0.1 manual, I could use a few parameters to include the D3 correction in the...
27 July 2024 5,748 0 View
It has been long known that EDC carbodiimide and NHS easter's half life agains hydrolysis are highly related to pH. However, very surprisingly, not yet found a paper giving a table/chart of their...
25 July 2024 8,738 0 View
I run mechanochemical reactions that involves the use of a large amount of catalyst (1:1 molar ratio to the reactant). When I try to understand the effect of amount of catalyst on the reaction, I...
23 July 2024 9,938 1 View
Hi, I am a PhD student working at Jagiellonian University, Faculty of Chemistry. My work is related to the development of new analytical methods for the quantification of short-chain fatty acids...
22 July 2024 5,492 6 View
Dear Researchers, My question is associated with the "MDCI" method in Orca. Please let me clarify my question using a simple example: Suppose we are going to perform CBS extrapolation using "!...
21 July 2024 1,632 0 View
what are the main points
10 July 2024 9,236 5 View
Hello dear colleagues and professors Please what is the recommended type of pseudopotentials for QE? ultrasoft or norm conserving?? And from where get all types of pseudos (us, nc, pbe,...
09 July 2024 9,541 5 View
Hi, Just curious to know that in chromatography, a chromatogram should be zoomed to what scale? 10 times of output , 50X or ..? Is there any regulation or general chapter which describes this?...
03 July 2024 3,119 6 View