19 Questions 56 Answers 0 Followers
Questions related from Omprakash Tanwar
Dear all, I have some compounds which good activity against some cancer cell lines (such as DU145 (Human prostate Cancer), MDA MB-231 (human breast cancer), etc. Now I want to search for the...
01 January 2019 8,170 7 View
I developed a device for cutting the TLC plates. This is my new invention and this design is registered. I wish to commercialize this product. Please let me know if it is useful for daily...
03 March 2018 7,340 15 View
Contract Research Organizations are growing very fast and drug discovery programs are exclusively using these services. However, I think that this culture is not able to produce the drug flow as...
01 January 2018 637 4 View
Rf values (TLC and HPLC) are used to identify the drug molecules. However this information can be of great value in medicinal chemistry and drug discovery. I think there's a great correction...
12 December 2017 6,817 12 View
Rapidly changing pharmaceutical R&D strategies put medicinal chemists in big trouble. Big pharmaceuticals now a days are solely depend on CRO industry for their discovery projects. In my view...
08 August 2016 5,919 4 View
Hi all, Now a days boronate chemistry is done routinely by most of the chemists. I am synthesizing boronates in my lab. We generally do not purify the boronates (only filter the reaction mixture...
07 July 2016 7,249 5 View
Dear all, I want to convert an ester to nitrile in one step. My structure contains base labile groups so I cannot use ester amine procedures. Is there any method through which I can easily convert...
01 January 2016 3,984 20 View
Reviews play a pivotal part in present day research. However, patent searching is a tedious job. I want to write a review on anti-diabetic compounds. I want to add patented anti-diabetic compounds...
05 May 2014 3,865 6 View
Reviews play a pivotal part in present day research. However, updated reviews take a lot of efforts to design. I want to write a review on anti-diabetic compounds which are currently progressing...
05 May 2014 8,769 5 View
We have isolated β -Glucuronidase (cleaves β-glycosidic bond) enzyme from E. coli and two other species. These enzymes were then tested for their glucuronidase activity on Glycyrrhizin (structure...
10 October 2013 9,145 9 View
I am trying to synthesize N-Protected Beta-Amino Ketones via mannich reaction. I tried to synthesize it using many reagents such as Sulfamic acid, Molecular Iodine, l-Prolin, PTSA etc., but I...
08 August 2013 4,316 5 View
I am writing a review article on some target, and in one of the research papers one figure is reported. I want to add this figure to my review article. Can i do this without permission to the...
07 July 2013 3,442 66 View
Anyone please search this article. link http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570260209/pdf DOI: 10.1002/jhet.5570260209 Azolopyrimidines and pyrimidoquinazolines from...
10 October 2012 9,840 5 View
I downloaded a database from Binding DB. It contains a lot of duplicate structures. How can I remove these duplicate structures?
07 July 2012 3,295 4 View
I have synthesized this type of compound and wanted to remove acetyl group from the NH group. I tried these 1N HCl to Conc, HCl,: The product degraded and did not get the desired product 1N NaOH...
07 July 2012 3,515 40 View
I am performing a reaction in which I am adding ammonia in a solution containing acetyl chloride and my starting material. I get my final product with ammonium chloride. The final product is...
07 July 2012 2,169 17 View
I want to synthesize this compound "1-(4-amino-2,6-diphenylpyrimidin-5-yl)ethanone". can anyone search on scifinder for this compound for possible route of synthesis. Thanks
06 June 2012 1,791 23 View
Can anyone tell me how to synthesize this molecule? 1-(4-amino-2,6-diphenylpyrimidin-5-yl)ethanone. Is it available in Scifinder?
05 May 2012 7,632 0 View
Can I develop homology model for DPP-8 and DPP-9 proteins? their ID are >gi|11095187 and >gi|90082057. Actually they are nucleotide sequences. I am working on development of novel DPP-4...
05 May 2012 4,476 9 View
