I need some references (preferably recent) about the preparation of 6-nitro salicylaldehyde. I will appreciate your assistance. I know that Riemmer Tiemmannn gives only 3-4% yield; and that a paper of the BCSJ of 1973 claims 24% overall yield in three steps. I'm looking for something better, if possible.
Desr Stewart,
Thanks for the info. We looked there before and were unable to find it; have checked again just a minute ago and still could not find it. Could you please provide me with the catalog number to make sure we both are talking about the same compound (with due respect)? Need it as a starting material for a total synthesis project. Will need more than 1 gram for sure.
No access to scifinder. This is the reason I request for some help. Thanks anyway.-
plz see Bio org med chem 2001 (11) 99-101 page nice procedure Hope it will work
Thanks for giving me appartunity.
RE: plz see Bio org med chem lett 2001 (11) 99-101 page nice procedure Hope it will work
Thanks for giving me appartunity.
For o-formylation of phenol: To a solution of nitrophenol (0.01 mol) and hexamethylenetetramine (0.01 mol) in distilled acetic acid (25 ml), distilled acetic anhydride (0.03 mol) was added. The mixture was boiled gently for 1 h., then allowed to cool to room temp. A mixture of 6N-HCl (10 ml) and methanol (5 ml) was added to the reaction and the reaction was warmed to ~80 C for 1/2 h. Add methanol (30 ml) and allow the mixture to stand for 1/2 h at room temp. Evaporate in vacuo and extract the residue with benzene. The benzene was evaporated and the product was purified by Column Chromatography. See
---Ishibashi, Fumihide; Miyoshi, Nozomi; Okahashi, Hidemitsu; Mizuno, Mika; Yamada, Michiyo; Katagiri, Masanao, Chemistry Express (1991), 6(1), 37-40.
Good luck
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