I'm going to edit a disease-causing mutation using CRISPR/cas9-base gene editing strategy for my PHD thesis. I'm going to replace 1608 bp of genome with nearly 3700 bp of donor template. Each of homologous arms is 1000 bp, Do you have similar experience? Is replasment of this large fragment possible using CRISPR/cas9 gene editing strategy, I would be wondering if you could direct me