I have a hydrophilic molecule, but it is not soluble in water. I tried a formulation of 5% DMSO, tween 80 1%, PEG 300 20%, and remaining water, but it is still not fully soluble. I've replaced tween 80 1% with tween 20 1%, but still, the molecule is partially soluble. I've attached the structure of my molecule herewith. Please suggest a good formulation to dissolve my molecule completely.
Perform a solubility screen by adding excess API in different single solvent systems and measuring the amount dissolved. Rank order the solvents in terms of solubility obtained. Then you can select a mixed solvent system by picking the solvents which gave you the desired/highest solubility.
try transcutol
or
Glycofurol
or
Chremphor RH 40
Also u need to go for higher surfactant concentration at 20 to 40 % w/v
Regards