Please, how can I dissolve the cake of chitosanoligosaccharide and TPP nanoparticle to determine the amount of drug in this cake?

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Ankit Javia

If your drug is soluble in 1 %v/v or 2% v/v acetic acid, then you can find drug content by dissolving chitosan/TPP cake (break this cake first by probe sonication and then dissolve) in acetic acid solution. Hope this will works.

Rémi Rosière

In strong acidic conditions (HCl 1N), it should work. Please find attached an article of our research group about this.