PRP injections accelerates healing of chronic non-healing ulcers by stimulating tissue regeneration through release of Platelet derived growth factor (PDGF), epidermal growth factor (EGF), platelet derived angiogenesis factor and platelet factor 4. There are reports that platelet also exerts antimicrobial effects. How this antimicrobial effects are exerted?
Part of the answer comes to how the PRP is prepared
Neutrophils phagocytose activated platelets so it is useful to exclude them from your PRP. However they also phagocytose bacteria.
PRP can be applied topically to the ulcer and will aid the healing process. It can also be applied to burns and will help stop secondary infection as well as speed up the healing process. It is one area of use where PRP that is prepared to include neutrophils has apparently been shown to be more effective since the beneficial effects outweigh the platelet phagocytosis effect
I have only heard this as I have not used it on ulcers/burns myself but it certainly makes sense!I cannot give you references
I have also heard that the PRP can be injected into the ulcer as well as applied topically
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