By the category is khown through wound healing;inflammation works as a decontaminating factor which helps the area of the ulcer be thereghly cleand from micro-organisms.While an skin secondary infectious bacreria invases the wound,prolonged increased level of proinflammatory cytokins eg. IL1 and TNF alpha besides an incomplete inflammation lead to insufficient decontamination and specifically subsequent increase in matrix metalloprotease.This process will result in ECM non-regeneration or at least some deficiencies in ECM synthesis as one of the important phases of wound healing.
The most common bacteria which complicate skin lasions are:
-Staphylococcus aureus
-Lansfield A & B beta hemolytic streptococci
-Pseudomonas aeroginosa
In some cases infections with MRSA will not response to vancomycin so one of the reasons under which antibiotics or plasma torch should be sellested;appears hear.
Also I think as in several chronic ulcers due to pseudomonas aeroginosa and staphylococcus aureus,biofilm generation of these miro-organism will protect or some how hide them from phagocytosis by PMNs; and sometimes competitionary inhibition will happen by administrating antibiotics;plasma torch can be indicated as an alternative or most commonly in conjunction with specific antibiotics.
The question is a research plan for a master's thesis about comparing the effects of plasma torch and antibiotics in the treatment of wounds by taking samples from hospitals in the holy city of Karbala