Lipmann 1941 introduced the cocept of sqiggle and ATP dependent phosphate transfers as modulators of metabolism. I find that inorganic phosphate (Pi) is the primary stimulator of fermentative metabolic remodelling. CD39 by activating ATP hydrolysis activates metabolic remodelling of multiple cells in microenvironment. While ATP is produced through enzymatic transfer of Phosphate group from phosphorylated organic substrates, ATP hydrolysis activates proton transfers and ADP transfers across the membranes.

Can some one tell me the dynamics of bond energies involved in phosphate ligation and breakdown of terminal phosphate groups in ATP?