Can anyone suggest me the precise and new anti-cancer target for docking of peptide type compounds. As per literature reports the chemical class of the above peptides are mitotic inhibitors. The BAX and BID along with Caspase 3 were highly expressed with peptides while in cytotoxicity studies. When the above genes are over expressing (Biomarkers) is an indication of apoptosis. Can I choose Caspase 3 as druggable target for these compounds and go for docking ?
Hello You might want to check out the below link for appropriate article.
Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors*
http://www.jbc.org/content/273/49/32608.full.html
If an article suggests the intracellular protein inhibition for the induction apoptosis in cancer would it be feasible to inhibit the pathway by inhibiting the membrane proteins or receptor tyrosine kinase, as the peptide based drugs are more of surface acting molecules
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