can this vaccine will be successful in Indian population? once when trial was conducted for nasal insulin in our hospital stage 3 trial it wasn't successful, the reason for it was the receptors were blocked due to air pollution. Is this vaccine have chances to work in south Asian population.

Thanks Dr Hermann Gruenwald

Dear Amar,

Thanks for your comment. It is a good point indeed. One solution would be to train patients (through product leaflet for example) to rinse & dry their nose before application of the vaccine. Any comments on this?

With respect of your question:

"Is this vaccine have chances to work in south Asian population.?"

I cannot see why not.

Amar Prashad Chaudhary

M. R. Mozafari

Dear sir,

I have developed one doubt, I am just a student so i have less knowledge, does rinse and drying of nose before application can helps to remove receptor blockage.

Dear professor Mozafari

It is an interesting idea. Alveolar macrophages as the professional APCs (antigen presenting cells) will be an appropriate target. Nevertheless, the choice of vaccine type as well as optimization of excipients for a successful pulmonary delivery will be challenging. In addition, cytokines secretion induced by the inhaled drugs should be meticulously monitored in the preclinical studies.

Wishing the best, for smoothing and rapid works.

Dear Dr Alireza Naderi Sohi

Many thanks for your technical points of view.

Can we have a chat on the topic?

Pls email me your contact numbers:

[email protected]