Hi everyone.
I am considering the area of fabrication and application of SPR (Surface Plasmon Resonance) - SERS (Surface-Enhanced Raman Scattering) hybrid devices as high sensitivity bio-sensors for a future postdoctoral investigation. In this context, I would like to know the opinion of an expert who can tell me about the application potential of this kind of technologies and their future perspectives for molecules detection.
Any comment is welcome.
Dear Simón Roa , they are already having a relevant role in our times, specially for detection of SARS-CoV2 in a fast and sensitive way. This approach is not new and plasmonic sensors have been used to detect virus, bacterias and biomarkers for cancer or other patologies or just to measure biomolecules. Please, have a look to the following recent reviews you may find useful:
https://www.nature.com/articles/s42003-020-01615-8
Article Dual Sensing Arrays for Surface Plasmon Resonance (SPR) and ...
https://ieeexplore.ieee.org/abstract/document/9285527/authors#authors
Combination of the high sensitivity of SPR with the structural information (and sensitivity) provided by SERS in a label free way, allow to widening their range of applications beyond biosensors, and actually they can be applied for detection of almost any molecule and in any field of study. Think for instance about the systems for detection of life biomolecules or life signatures in Mars or other planets or in the space.
Some of these life-related molecules could be chiral and new sensors with chiral properties could be useful for their detection.
An extensive review (about SERS) present and future applications you could find interesting is the one from 2020 in ACS-Nano, signed by good share (but not all) of the more prominent authors in the field at the time:
Article Present and Future of Surface Enhanced Raman Scattering
Additionally the introduction of new materials and alloys or composites together with new designs of nanostructures or metasurfaces is widening the range of applications. New spectrometers and softwares are key elements to improve the scope and power of the field.
My own expertise is related to the design and fabrication of these kind of sensors (SERS) and we have applied them to a variety of analytes, some already recorded in our work and some still in progress, including some biomolecules.
The potential of the field is what makes it so appealing.
Hope this helps.
We have a recent publication addressing dual-sensing capability of SPR-SERS, see Article High-Sensitive Assay of Nucleic Acid Using Tetrahedral DNA P...
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SERS biosensors are research hot-spots now, Prof. Zhao Yiping and Gomez have done many perfect works on this field such as virus. SERS biosensors can be developed in many bio-fields including diagnose of cancer markers and SARS-CoV-2. Our groups also developed SERS method to detect SARS-CoV-2 and their infectiousness. Article Human ACE2-Functionalized Gold “Virus-Trap” Nanostructures f...
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