Does anyone have any experience with conducting the novel object recognition test while administering a drug that has a short duration of action (so that it may "wear off" during the seemed-to-be "obligatory" 1 hour of retention time between the "training" session [T1] and the "test" session [T2])? Should it be administered nevertheless, before the T1? Or maybe after the T1? Or in any other way?
If you want to be sure that the drug is working both during T1 and T2, why don't you do two injections, one before T1 and second before T2?
I think it depends on which stage of memory formation you want the drug to be active. If you want it to active during acquisition, then inject before training (T1). If you want it to be active on consolidation, you should inject it right after T1. But if you want it to be active during retrieval, inject it right before testing (T2). If you don't know the mechanism of the drug, maybe you should consider doing all of these possibilities and find out on which stage of memory formation the drug works best.
I agree with Fernanda Barros-Aragão . Time of drug administration depends on the memory process you want to study. By injecting before T1, after T1 and before T2 you can act, respectively, on acquisition, consolidation and retrieval. I would add that if you inject after T2 (i.e. after memory reactivation) you can act on reconsolidation.
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