The expression of telomerase in mammals is restricted to certain early stages of embryonic development and in adults, to certain adult stem cells compartments and the highly proliferative cell lineages, such as lymphocytes, keratinocytes, or germ cells. This property makes that most of our body's cells have a limited life.Telomere Length is one of the main barriers against the uncontrolled proliferation, and, in fact, 90% of the tumoral processes are studying at some point with an anomalous reactivation of the telomerase activity.These data highlight the close dependence of the acquisition of a limitless replicative potential and tumorigenic ability of the cells, while the mere reactivation of telomerase is not an transforming event per se.
I think that they should seek chemical inhibitors of telomerase that can be localized and controlled in order to prevent the emergence and progress of tumoral carcinogenic manifestations without influence at the expense of longevity or tissue homeostasis.
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