Metformin's anti-cancerous properties have been demonstrated in various cancer cells in vitro, such as lung, pancreatic, colon, ovarian, breast, prostate, renal cancer cells, melanoma, and even in acute lymphoblastic leukemia cells.
It was suggested that the tumoral microenvironment is associated with long-term outcome in primary and metastatic tumors.Metformin reduces inflammatory microenvironment Is regulated microenvironment with metformin reprogramme malignant cancer Cells toward a benign phenotype.
Dear Mesut
Can you provide me the reference about metformin reducing the inflammatory microenvironment.
Thank you
Tomas
Dear Tomas
please find attached references
1: Erices R, Cubillos S, Aravena R, Santoro F, Marquez M, Orellana R, Ramírez C,
González P, Fuenzalida P, Bravo ML, Oliva B, Kato S, Ibañez C, Brañes J, Bravo E,
Alonso C, García K, Arab C, Torres VA, Godoy AS, Pereira J, Bustos G, Cardenas
JC, Cuello MA, Owen GI. Diabetic concentrations of metformin inhibit
platelet-mediated ovarian cancer cell progression. Oncotarget. 2017 Mar
28;8(13):20865-20880. doi: 10.18632/oncotarget.15348. PubMed PMID: 28209916;
PubMed Central PMCID: PMC5400552.
2: Chiang CF, Chao TT, Su YF, Hsu CC, Chien CY, Chiu KC, Shiah SG, Lee CH, Liu
SY, Shieh YS. Metformin-treated cancer cells modulate macrophage polarization
through AMPK-NF-κB signaling. Oncotarget. 2017 Mar 28;8(13):20706-20718. doi:
10.18632/oncotarget.14982. PubMed PMID: 28157701; PubMed Central PMCID:
PMC5400538.
3: Curry J, Johnson J, Tassone P, Vidal MD, Menezes DW, Sprandio J, Mollaee M,
Cotzia P, Birbe R, Lin Z, Gill K, Duddy E, Zhan T, Leiby B, Reyzer M, Cognetti D,
Luginbuhl A, Tuluc M, Martinez-Outschoorn U. Metformin effects on head and neck
squamous carcinoma microenvironment: Window of opportunity trial. Laryngoscope.
2017 Feb 10. doi: 10.1002/lary.26489. [Epub ahead of print] PubMed PMID:
28185288.
4: Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. Efficacy of PD-1
Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia. Cancer
Immunol Res. 2017 Jan;5(1):9-16. doi: 10.1158/2326-6066.CIR-16-0103. Epub 2016
Dec 9. PubMed PMID: 27941003; PubMed Central PMCID: PMC5340074.
5: Banerjee P, Surendran H, Chowdhury DR, Prabhakar K, Pal R. Metformin mediated
reversal of epithelial to mesenchymal transition is triggered by epigenetic
changes in E-cadherin promoter. J Mol Med (Berl). 2016 Dec;94(12):1397-1409. Epub
2016 Aug 17. PubMed PMID: 27534967.
6: Talarico G, Orecchioni S, Dallaglio K, Reggiani F, Mancuso P, Calleri A,
Gregato G, Labanca V, Rossi T, Noonan DM, Albini A, Bertolini F. Aspirin and
atenolol enhance metformin activity against breast cancer by targeting both
neoplastic and microenvironment cells. Sci Rep. 2016 Jan 5;6:18673. doi:
10.1038/srep18673. PubMed PMID: 26728433; PubMed Central PMCID: PMC4700497.
7: Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I,
Deshpande V, Jain RK, Fukumura D. Metformin Reduces Desmoplasia in Pancreatic
Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. PLoS
One. 2015 Dec 7;10(12):e0141392. doi: 10.1371/journal.pone.0141392. eCollection
2015. PubMed PMID: 26641266; PubMed Central PMCID: PMC4671732.
8: Qu H, Yang X. Metformin inhibits angiogenesis induced by interaction of
hepatocellular carcinoma with hepatic stellate cells. Cell Biochem Biophys. 2015
Mar;71(2):931-6. doi: 10.1007/s12013-014-0287-8. PubMed PMID: 25326336.
Thank you for the numerous references. They will be very useful for my work.
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