A third study published on September 19, 2025 by a different group of scientists led by Prof Jihye Yun at University of Texas MD Anderson Cancer Center (in last 2 months) further proves Prof Dr. Reginald B. Little's (RBL) theory of stable isotope carbon-13 (13C) causing and accelerating cancer and it involves a forth different type of cancer: colorectal cancer and liver cancer. The other two studies measured that 13C accelerated lung cancer, brain cancer and skin cancer. The new experimental paper by Juhye Yub et al fed mix of glucose and fructose to cancer cells in mice in vivo and measured the cytosolic irreversible conversion of glucose to sorbitol by enzyme aldose reductase (AR) and reversible fructose to sorbitol by enzyme sorbital dehydrogenase (SORD). See { Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD | Nature Metabolism } The experimental method for the first time observed the isotopic trace when both fructose and glucose are fed to the mice in relative amount as from high fructose corn syrup or sucrose as in sugar sweenten daily soft drink. They observed directly the prior theory of RBL of 13C from the glucose and fructose enriching in the sorbitol intermediate. But the reversibility of the sorbitol formation from the fructose via SORD caused greater formation and enrichment of 13C in sorbitol from the fructose. RBL had previously predicted by his theory that fructose is more carcinogenic than glucose due to fructose contributing more 13C than glucose. This new experiment confirms RBL's theory and prediction as the fructose is measured to almost exclusively enrich the sorbital intermediate with 97% conversion and 13C at all 6 carbons in the sorbitol. But the glucose contributed only tiny 13C enrichment of the sorbitol. Reginald B. Little here notes that the resulting heavily 13C enriched sorbitol is transported to the liver where it is known that the liver converts such biomolecules to lipids. The heavily 13C enriched sorbitol entering the liver is basis of RBL's theory of the metastatic induction of cancer in the liver via the 13C enriched sorbitol produced by the colorectal cancer cells. RBL here further notes that the liver converts the 13C enriched sorbitol to lipids and some of these lipids build cell membranes of offspring cancer cells during replication of the cancer and such 13C enriched lipids in the cell membranes are explained here a mechanism for fractionative 15N and 14N amines to deplete 15N in the cancer cells as was previously measured by RBL of depletion of 15N in DNA of cancer cells. The 15N depletion is a basis for normal cells rewiring for transforming to cancer cells. I, Reginald B. Little (RBL), am very happy to see my prior theory of 13C enrichment and 15N depletion causing and accelerating cancer. - Reginald B. Little