We've recently implemented a new feature in EventIDE, our visual programming environment for behavioral and neuroscience experiments. This update enables real-time phase-locked stimulus presentation, allowing closed-loop stimulation based on biosignals like EEG (e.g., alpha, theta and other bands), PPG, respiration and more.

The system supports:

• Locking stimuli to specific phase(s) of ongoing oscillations in multiple channels, with sub-cycle precision
• Integration with any biosignal hardware supporting live streaming
• Customizable experiment protocols via both visual design and inline scripting
• Real-time monitoring and dynamic control of stimulus delivery

This method is particularly useful for:

• Closed-loop neurostimulation
• Neurofeedback experiments
• Brain-state-dependent perceptual/cognitive paradigms
• Exploring the temporal dynamics of attention, perception, sleep or neural responsiveness

We've also developed a companion analysis tool, PhInsight, which allows in-depth post-hoc visualization and validation of phase-locking results.

A full demo is available here, featuring an experiment using alpha-band EEG: 🎥 https://youtu.be/wSTYbo82Edk More details: https://www.okazolab.com/developer-blog/integrated-closed-loop-platform-for-brain-stimulation-using-the-phase-locking-technique

We’re interested in connecting with others working on closed-loop designs or phase-locked stimulation. Would a tool like this be useful in your research? What challenges have you faced in achieving reliable real-time phase-locking?