In January 2000, US cancer experts Doug Hanahan and Bob Weinberg published a seminal paper called “The Hallmarks of Cancer”, which outlined six of these common features. The article appeared in the Millennium issue of the journal Cell, and it went on to influence a generation of cancer researchers. Then, research – and our understanding of cancer – has moved on. Hanahan and Weinberg have been writing an update, and Hanahan shared some of the pair’s latest thinking with us. They’ve now added four more characteristics to their list to end up with 10 Hallmarks of Cancer. do you suggest any other areas where we could propose the next hallmark/s of cancer?
http://www.cell.com/abstract/S0092-8674(11)00127-9
The debate is already on (see link).
https://www.researchgate.net/post/What_would_you_add_or_change_for_a_complete_list_of_the_hallmarks_of_cancer
Otto Warburg claimed that a characterstic for cancer was the ability to survive in hypoxic environment. I worked on lactate dehydrogenase as tumor marker because LDH allows for production of ATP without use of oxugen. Many of the signal transduction pathwys demand phosphorylaions and that would not be possible without access to ATP. I made many clinicit might reflect a important biologic aspect of cancer biology that is not shown in the scheme despite its many details.al observaions on testis cancer and LDH and
Life style is a risk factor for cancer. The hallmark of cancer adr€ss cellular abnormalities characteristic for the cancer cells.
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