Various forms of entrainment are being incorporated into treatment modalities, but only limited and dated empirical data is offered. My question is, what significant effect may these therapies have, do they impact glutamate receptors to influence or balance the relationship between serotonin and domaine transmitters, improve distribution, address CREBS and Delta-FosB protein alterations, or improve plasticity? Is there influence in pathway generation, or alteration of dendritic spines - these are some of the claims made by providers.