Dear Raghavendra,

You can select one of the examples depicted in the following text:

POTENTIAL DRUG CANDIDATES FOR GASTRORETENTIVE DRUG DELIVERY

SYSTEMS

1) Drugs those are locally active in the stomach e.g. misroprostol, antacids etc.

2) Drugs that have narrow absorption window in gastrointestinal tract (GIT) e.g. L-DOPA, para aminobenzoic acid, furosemide, riboflavin etc.

3) Drugs those are unstable in the intestinal or colonic environment e.g. captopril, ranitidine HCl, metronidazole.

4) Drugs that disturb normal colonic microbes e.g. antibiotics against Helicobacter pylori.

5) Drugs that exhibit low solubility at high pH values e.g. diazepam, chlordiazepoxide,

verapamil HCl.

For more on this topic, please see attached file.

Hoping this will be helpful,

rafik

thank you dear Rafik Karaman sir for your rhythmic response. I need your co-operation in future also. nice to meet you via this conversation. whether the above mentined drugs are having less literature work and suitable for Ph.D thesis right.  

Dear Raghavendra,

I want to include few points herewith the drug solubility in the stomach should be high and it should be stable at the stomach pH.

Thank you and all the best.