Maternal diagnosis of VZV was based on clinical symptoms and signs, positive specific IgM and IgG and positive PCR for VZV on samples from cutaneous lesions.
The newborn, was born at 37+5 weeks and IgG and IgM for VZV were tested two times in different laboratories.
No evidence of immunodeficency in mother and child.
Was the mother tested for VZV IgG and IgM around the time of birth as well ?
The immunologic competence of the neonate progresses rapidly in the first three months of life, as the cells involved in acquired immunity mature and gain antigenic experience. During this period, the neonate mainly depends upon components of the innate or antigen-independent immune system, including phagocytes, natural killer cells, antigen presenting cells, humoral mediators of inflammation, and complement [1-3], therefore, the adaptive antigen specific immune reaction could be not efficient to produce specific antibodies against the virus
Maródi L. Neonatal innate immunity to infectious agents. Infect Immun 2006; 74:1999.
PrabhuDas M, Adkins B, Gans H, et al. Challenges in infant immunity: implications for responses to infection and vaccines. Nat Immunol 2011; 12:189.
Ygberg S, Nilsson A. The developing immune system - from foetus to toddler. Acta Paediatr 2012; 101:120.
Lewis B, Wilson CB. Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection. In: Infectious diseases of the fetus and newborn, 5th ed, Remington JS, Klein JO (Eds), WB Saunders, Philadelphia 2001. p.25.
Hi
dear doctor
Your answer is yes!
1. After 8 wk or more of gestation mother with evidence of immunity against varicella will transfer maternal IgG Ab to their fetus, thus their newborn infants already have positive Anti-varicella Ab that reflect passively-acquired maternal Ab (The IgG of the newborn is solely of maternal origin)
2. On the other hand, maternal Ab titers are affected by her nutritional and immune
status,
3.In rare circumstances, mother may have low or absent levels of circulating IgG antibody. In these cases, the mother cannot transfer protection to her infant
4. You should check IG profile of mother in addition to serum IgG/IgM level of both infant and her mother simultaneously
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