There are several molecular forms of Cholecystokinin (CCK), of which CCK-8 and CCK-33 are the two frequently used molecular forms in pharmaceutical infusion studies to induce fullness and reduce hunger in human/animals.

However, in dietary studies, which involve participants to consume a test meal, which molecular form of postprandial plasma CCK should we assess? What are the methods available? What are the advantages and disadvantages?

Many dietary studies have not been explicitly stating the molecular form of CCK analysed, although some did mentioned CCK-8, CCK-33 or total CCK being measured.

So how should be make decision around which form of postprandial plasma CCK should be analysed in appetite studies?