Hello all,
I have a RCT data set as follows:
IV = Group (Intervention A, Intervention B, Control)
DV = Blood biomarker, Inhibitory control, working memory
I have two research aims.
1) Comparing the effect of interventions on DVs
2) Investigating the mediating effect of blood biomarker on inhibitory control and working memory
My results are as follows:
1) Interventions A and B decreased blood biomarker level.
2) Only Intervention A was effective on inhibitory control.
3) None of the interventions changed working memory.
In this case, I have three questions for mediation analysis.
1) Would performing mediation analysis only for inhibitory control make sense?
2) When analyzing mediation for inhibitory control, should I include only the intervention outcome that shows a significant effect (intervention A)?
3) Which method would be more advantageous for analysis (SPSS, AMOS, etc.)?
Thank you for your help.
Considering your plan for mediation analysis on inhibitory control, I recommend focusing on Intervention A. It's the only intervention that showed a significant effect, so exploring its potential mediation by the blood biomarker could be quite insightful.
In mediation analysis, we typically include only the intervention variable that shows a significant effect on the outcome variable of interest. Since only Intervention A was effective on inhibitory control, you would include this intervention variable in the mediation model. However, it's essential to interpret the results cautiously and consider potential explanations for why Intervention B did not have a significant effect. This approach will help ensure that your analysis is accurate and meaningful.
Article The moderator-mediator variable distinction in social psycho...
Hayes, A. F. (2017). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. Guilford publications.
Check here https://stats4edu.com/services/structural-equation-modeling/
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