Hi, may I know which part of the gene region you are targeting to control the circadian rhythm? What is the model organism used?
Maye You know the gens to control of computer games....!? It is absolute simplification of human behaviour!
There's no single gene controlling circadian rhythm's but moreover a complex network of negative and positive intertwined feedback loops. Model organisms include the fruit fly drosophila, yeast, mice, hamsters e.g. Phodopus sungorus to name the biggest players here. You're proud of to name the biggest players here. check pub MED even google
Not a single gene, not a Gene but several genes (Per, Tim, Clock, Cry .... ) working in a very complex way.
The SCN generates circadian rhythms by means of a transcriptional-translational
feedback loop. In short, the mechanism is formed by the basic helix-loop-helix (bHLH) Per-Arnt-Sim (PAS) domain containing transcription factors circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), which activate the expressionof three Period (Per 1–3) and two Cryptochrome (Cry 1–2) genes by
binding to their E-box (5′-CACGTG-3′) promoter elements. The PERIOD
(PER 1–3) and CRYPTOCHROME (CRY1–2) proteins rhythmically accumulate,
heterodimerize, and translocate to the nucleus to suppress
their own transcription by interactionwith the CLOCK:BMAL1 complex.
CLOCK/BMAL1 also rhythmically control the expression of nuclear receptors,
such as REV-ERBα/β (reverse transcript of erythroblastosis
gene) and RORα/β/γ (retinoic acid related (RAR) orphan receptor),
which in turn repress and activate Bmal1 expression, respectively, conferring
amplitude and robustness to the oscillations in the molecular
clockwork. From a molecular point of view, light activates the expression
of several genes in SCN with different expression patterns
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