Hello,
I am looking for a publicly available database that contains data on maternal demographics as well as their children's health outcomes, cancer incidences, etc.
Any suggestions?
Best,
Amr
INTRODUCTION
Childhood cancer has been increasing in
Scotland. A published report estimates that
its incidence has risen from an age standardised rate of 120 cases per million population in the time period 1983–1987 to 161
cases per million in the period 2003–2007.1
The reason for this increasing trend remains
unexplained as the aetiopathogenesis of
childhood cancer is poorly understood. As
most of the children present with cancer in
the first few years of life, epidemiologists
hypothesise that prenatal and perinatal exposures may have a part to play in its pathogenesis. The evidence surrounding this is,
however, conflicting. While some researchers
have found associations of younger maternal
age at delivery2 maternal anaemia,3 4 history
of miscarriage,256 maternal overweight7 and
smoking8 with some childhood cancers,
others have found no such associations.9–11
Fetal growth is perhaps the most investigated
perinatal risk factor for childhood
cancer7 12 13; but the authors report conflicting results. While specific central nervous
system tumours have been found to be associated with intrauterine growth restriction
(IUGR), the overall risk was small.12
Therefore, apart from the associations with
Down’s syndrome and in utero exposure to
radiation, research into the maternal and
perinatal risk factors has remained inconsistent, the results limited by small sample sizes
and recall or reporting bias.
Our objective was, therefore, to investigate
the maternal and perinatal risk factors for
childhood cancer, specifically to examine the
effects of IUGR, preterm birth and birth
asphyxia on the development of childhoodcancer in the offspring, taking advantage of the opportunities offered by record linkage of a cancer registry
with a local birth register.
odel.
Conclusions: Younger maternal age, maternal
smoking, delivery by caesarean section and low Apgar
score at 5 min were independently associated with
increased risk of childhood cancer. These general
findings should be interpreted with caution as this
study did not have the power to detect any association
with individual diagnostic categories of childhood
cancer.
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