Lilly’s antibody for COVID-19 protection starts nursing home trial
LY-CoV555 is a potent, neutralizing IgG 1 monoclonal antibody (mAb) directed against the spike protein of SARS-CoV-2. It is designed to block viral attachment and entry into human cells, thus neutralizing the virus, potentially preventing and treating COVID-19.
Lilly intends to test this first antibody as well as other neutralizing antibodies against SARS-CoV-2 over the next several months.
Lilly intends to test both single antibody therapy as well as combinations of Lilly antibodies (sometimes known as antibody cocktails) as potential therapeutics for COVID-19. CAN READ MORE IN THIS
https://pharmaphorum.com/tag/ly-cov555/
https://www.prnewswire.com/news-releases/lilly-initiates-phase-3-trial-of-ly-cov555-for-prevention-of-covid-19-at-long-term-care-facilities-in-partnership-with-the-national-institute-of-allergy-and-infectious-diseases-niaid-301104445.html
LY3819253 = (LY-CoV555)
https://clinicaltrials.gov/ct2/show/NCT04411628
LY3819253 is a human antibody that targets the SARS-CoV-2 spike protein. It was derived from human B cells from convalescent patients.
The placebo-controlled study (NCT04411628) will assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of LY-CoV555 following a single dose in patients hospitalized with COVID-19.
JS016 is a human monoclonal antibody that targets the SARS-CoV-2 spike protein and blocks binding of the virus to host cells.
The antibody was identified by screening B cells from convalescent COVID-19 patients, and engineered to introduce LALA mutations to silence the Fc portion. JS016 was shown to provide protection from SARS-CoV-2 infection when administered to rhesus monkeys (Shi et al. Nature 2020).
The Phase 1 clinical study will evaluate the tolerability, safety, pharmacokinetics and immunogenicity of JS016 in healthy volunteers.
JS016 is specific to the SARS-CoV-2 surface spike protein receptor binding domain and can effectively block the binding of viruses to host cell surface receptor ACE2.
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