Lower current for larger diameter DNA nanopores?

Naresh Niranjan Dhanasekar @Naresh_Dhanasekar

10 October 2018 1 2K Report

I have been working on a DNA channel which has an internal diameter of about 10 nm, and a length of about 60 nm. However, the conductance what i observe in single channel electrophysiology is about in the range of 1.0 to 1.2 nS only. Is there any technical reason for channel with larger internal diameter exhibit lower conductance?

Sheng-Nan Wu

Biophysical properties of of membrane electroporation-induced inward currents (see attached for your reference)

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