Indeed, the problem of side effects (e.g., neuropathy development) is important. The problem has long existed, and still has not been solved. Please meet with experience in solving problems in different years.

Vladimir

Dear Terry Jones:

according to current guidlines, there are presently only two unequivocal  recommendations for CIN prevention: ample (pre-)hydration and to use the lowest CM dose possible, whereas none of the pharmacological means suggested so far is supported by sufficient evidence.

Please find attached a review on mechanisms, risk factors, and prevention of CIN.

Best wishes

Erdmann Seeliger