We all know oncological outcomes of early prostate cancer with surgery and radiation, what is the opinion of the house about the early and late complications in each group?
This topic causes great debate & conflict between urologists & radiation oncologists - each would consider their own modality to be best. Truth is we dont have reliable comparative data.
When advising my patients, I firstly draw attention to my bias/conflict of interest as I am a surgeon & offer opportunity to consult a radiation oncologist.
Then I use the following to help guide decision-making:
Age: younger (ie 70 or so) - prefer Radiation
Co-morbidity: similar consideration as above, but less well defined
Large prostate or significant obstructive symptoms: prefer surgery or at least consider TURP before radiation
Higher risk cancer: some rationale for surgery first then radiation if needed (harder to do other way around)
Bowel disease like IBD: prefer surgery
Prior surgery (eg rectal resection)/mesh/pelvic fracture: prefer radiation
Beyond that, individual patient preference for type of treatment, side-effects (present for both treatments), recovery period as well as convenience/availability also come into play - no absolute right or wrong, important that patient feels comfortable with decision (some end up never being able to decide!)
Thank You, Shomik Sengupta, Dr.Shomik, Thank you for your replay,
regarding point 3, do you do TURP for large prostate when you have decided for radiation? In your practice have you seen more complications after TURP ( with EBRT or EBRT +BT combination ? )
If the prostate is large & the man has obstructive symptoms, then yes. Best time to do the TURP is prior to the radiation. Certainly there is a higher risk of complications such as bladder neck contracture
I inform patients that for localsied disaese eitheris a suitable option but the side effect prophile is the biggest consideration. RTX tends to have later onset of side effects and for younger men this needs to be considered as the effect can be significant. SX tends to have instant side effects that with time and councelling most are managed.
David Heath Valid Points , for younger patients are more likely to benefited from surgery as long term side effects of radiation are still not known fully ?
one more thing do you tell your patients that your patient is likely to have 1-4 % long term of second malignancy when radiation is given more so in younger patients ?
We discuss the risk of secondary maligancy from RTX but the radiation oncologist discuss this further at time of consultation once referred from urology.