I am working on PVA/nanocellulose/Ag nanocomposite films for antimicrobial food packaging. I have come across the reviewer with following comment
'I think the degradation experiment is necessary to understand the potential risk of cytotoxicity. Both PVA and cellulose are hydrophilic polymer which will be swelling drastically in contact with water. During the practical utilization of such packing materials, the swelling of packing membrane may accelerate the detachment of Ag nanoparticles into food'
You can probably refer to chapter 4 (Antimicrobial food packaging) of this book
Novel Food Packaging Techniques
and also this review might be good
Review of antimicrobial food packaging
https://doi.org/10.1016/S1466-8564(02)00012-7
Review of attached paperArticle Antimicrobial and antioxidant properties of polyvinyl alcoho...
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