The power-domain NOMA is similar to CDMA with correlation 1 and different power levels, so successive interference cancellation (SIC) operation (used in CDMA receiver) is used in the NOMA receiver.
Often the number of NOMA users in one resource is limited 2~3 because too many NOMA users in one resource causes excessive interference and processing delay/error propagation due to SIC.
Non-Orthogonal Multiple Access is an important technique for the next generation of wireless communications and it has many advantages. On the other side, NOMA gets back the data from users depending on a technique called successive interference cancellation (SIC). This technique causes increase in the number of errors because of error in single user decoding using SIC. This disadvantage leads to the limitation of maximum number of users.
My simple take on this issue is that this technique causes an increase in the number of errors because of error in single-user decoding using SIC. This demerit leads to the constraint of the maximum number of users. I hope it helps