Both collagenases and cytokines are mistakenly regarded as facilitators of metastatic spread of tumors. Tumor cell itself has the remnants of gene regulation and the adjacent tissues are partners in the upregulation of estrogen signaling and DNA restoration in tumors. Collagenases help the arrival of cytokines and other mediators aiming the restoration of the genomic machinery in tumors and self directed death. Cytokines activate aromatase enzyme for stimulation of estrogen synthesis, while an increased estrogen level silences inflammation and improve DNA stability even in tumor cells. In conclusion; there is no parallelism between the activity of collageneses or cytokunes and tumor spread.