Ultrasonic separation is a very simple and effective method for isolating the target component from a mixture that affects the extraction rate.
However, depending on the strength, there is a literature that ultrasonic irradiation generates OH radicals and H₂O₂, and trace amounts of free chlorine are generated in dichloromethane and chloroform.
However, there is a literature that raises the extraction rate by irradiating ultrasonic waves to such chlorine-based solvents.
Is it better not to use chlorinated solvents and ultrasonic irradiation together to extract weak and delicate substances such as alkaloids?
In one document, dichloromethane extraction was performed with the intensity reduced to 45 kHz.
Please give us your opinion.
It is well known that ultrasounds induce sonocavitation (check my papers). However scientists focused on analytical chemistry often don't include this effect. You should compare recovery for standard solutions at 2-3 conc. levels for few solvents with/without ultrasonication for your analyte. That is all.
Regards
GB
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