We have also worked with silymarin but we have improved its oral availability through minsing it with organic solvents like propylene glycol, phospotitylcholine, CMC etc. However, these organic preparations marginally improved the bioavailability of SIL But we haven't tried it through i. p.? I don't think it s achievable via i. p. route unless u get the vehicle with complete solubility of SIL
yes we have worked with silymarin for invivo antioxidant activity in rats as well as for hepato protective activity in rats in which we have estimated GSH, SOD, CAT values