We have also worked with silymarin but we have improved its oral availability through minsing it with organic solvents like propylene glycol, phospotitylcholine, CMC etc. However, these organic preparations marginally improved the bioavailability of SIL But we haven't tried it through i. p.? I don't think it s achievable via i. p. route unless u get the vehicle with complete solubility of SIL