What are the methods to improve the degree of N-methylation reaction of aliphatic amines using formaldehyde formic acid as raw materials or methanol and catalyst as raw materials?
Yes, there are a few methods that can increase the N-methylation response of aliphatic amines. One method is to use a stronger methylating agent, such as dimethyl sulfate or methyl iodide, to facilitate the reaction. Another method is to use a higher temperature during the reaction, which can increase the rate of the reaction and improve the yield. Additionally, using a higher concentration of the amine substrate can also improve the reaction efficiency. However, it is important to note that these methods may also increase the risks associated with the reaction, such as toxicity and safety hazards, and should only be attempted by trained professionals in a safe laboratory setting.
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