human papilloma viral infection is usually treated by local treatment, but if there is widespread infection with involvement of mucus membranes,there might be more indication for systemic treatment.
you may develop a clinical trial for that purpose. So far, no guideline is available.
In case of AIDS, combination of other antiviral drugs (CMV, HSV) might play a dual role.
The closest to systemic treatment would be therapeutic vaccination of persons with HPV-related cancer or high grade dysplasia. There are a number of clinical trials in this area which can be found here https://www.clinicaltrials.gov/ct2/results?term=therapeutic+HPV+vaccine&Search=Search.
No systemic treatments are recommended or available for HPV infection. Only the vaccination should be considered an "indirect" systemic treatment in selected patients. Another example of indirect systemic treatment could be considered the cART in HIV patients with GW, because this seem to enhance the response to physical treatment of the lesions. Unfortunately, no data from accurate studies were also available to understand the role of cART, as systemic treatment, on the natural clearance of HPV in these patients.
Early in my career I developed and treated a number of mostly children with Juvenile papilloma of the larynx with an autologous papilloma tumor derived vaccine. (Juvenile papilloma of the larynx, in the Am J Dis Child. 1971 May; 121(5):417-9. PMID: 4326367; Autogenous vaccine in the treatment of laryngeal papilloma in Current Chemotherapy/Immunotherapy, 1981 1099-1101). Laryngeal papilloma is a complication of maternal HPV genital infection, frequently presenting as condyloma accumulate (CA) which is acquired by the infant during the birthing process at the time of vaginal delivery. The current standard of treatment is laser therapy which has replaced the need for an autologous vaccination possibly by the in-site-to creation of an autologous vaccine like response as a byproduct of the laser treatment. In addition, I had prepared several autologous vaccines for patients with serve recurrent CA exhibiting similar improvement from a course of vaccinations. It is possible that currently available HPV vaccines could be administered more frequently or even locally at the site of HPV infection aimed at generating an immune response that is therapeutic at first than developing a preventive response.
Should we believe that HPV vaccine may help towards increasing whole body answer...?
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