Efflux pumps seems to be one of the resistant mechanism adopted by bacteria. Even though EPI's (efflux pump inhibitors) underwent more basic research and even clinical trials none of them have been licensed to market. In this scenario, what kind of structural nucleus and functional groups of drug substances play effective role in efflux pump inhibition mechanism? Can anyone suggest?
Thank you Mohamed Medhat.. Good review article on the related topic.
Hi Ms. Ekambaram
You sould check this review out
It's organized very good and provides a list of Inhibitors worked on
Efflux pumps may be specific for one substrate or may transport a range of structurally dissimilar compounds (including antibiotics of multiple classes); such pumps can be associated with multiple drug resistance (MDR). In the prokaryotic kingdom there are five major families of efflux transporter: MF (major facilitator), MATE (multidrug and toxic efflux), RND (resistance-nodulation-division), SMR (small multidrug resistance) and ABC (ATP binding cassette).
- Badges
- Science topic
- Similar topics
- Biological Science
- Microbiology