I want to conduct research on the diagnostic performance of some tests. I want to calculate sample size by using the sensitivity and specificity of the test in the previous studies. So Is there any software or formula for sample size determination by using sensitivity and specificity?
I will look forward to your help
Thank
Hello Tahir,
Since sensitivity and specificity are proportions, you could use binomial theorem to derive a requisite sample size for estimating a given proportion, with a maximum tolerable error and a target confidence level. If you wanted to be conservative, presuming that the population value was .50 would give the largest requisite sample size. There are a number of online calculators for this sort of determination (such as: https://select-statistics.co.uk/calculators/sample-size-calculator-population-proportion/)
If you elect to estimate the target population proportion by looking at extant studies, choose whichever statistic (sensitivity, specificity) is lower (closer to 50%), so as to have at least the desired precision for both.
Good luck with your work.
Hi Tahir Eyayu
Sensitivity is the fraction of observed positive outcome cases that are correctly classified; while specificity is the fraction of observed negative outcome cases that are correctly classified (Readings: Hanley and McNeil, 1982; Faraggi & Reiser, 2002; and Cook & Rajbhandari, 2018). As already mentioned by Prof David Morse , 0.5 cut off value is recommended as optimal.
Hello Tahir,
The review paper of Mohamad and Adnan "Requirements for Minimum Sample Size for Sensitivity and Specificity Analysis" provides sample size tables with regards to sensitivity and specificity analysis. These tables were derived from the formulation of sensitivity and specificity test using Power Analysis and Sample Size (PASS) software based on the desired type I error, power and effect size.
I hope it helps you...
Article Requirements for Minimum Sample Size for Sensitivity and Spe...
Good luck
hello, I have no answer.... I have a question about, how can I download SPSS on my mobile? Regards
Hanaw Amin ,
IBM SPSS is commercially available, copyrighted software, and is not available for free - an option would be to try accessing it from your university at no cost if that university has it and shares it with its registered students or staff members
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