Asparaginase may affect  fertility (being able to get pregnant or father a child). .

Contraception

we should advise the patient not to become pregnant or father a child during treatment. This is because the drugs may harm a developing baby. It’s important to use contraception during and for a few months after chemotherapy.

In mice and rats ELSPAR has been shown to retard the weight gain of

mothers and fetuses when given in doses of more than 1000 I.U./kg (the recommended human dose).

Resorptions, gross abnormalities and skeletal abnormalities were observed. The intravenous administration of 50 or 100 i.U./kg (one-twentieth or one-tenth of the human dose) to pregnant rabbits on Day 8 and 9 of gestation resulted in dose dependent embryotoxicity and gross abnormalities. There are no adequate and well-controlled studies in pregnant women. ELSPAR should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

REFERENCE:

Perry MC. The Chemotherapy Source Book. 5th edition. Lippincott, Williams and Wilkins. 2012. Scottish Medicines Consortium scottish medicines.org.uk (accessed July 2013).