Dendritic cells (DCs) are the most potent antigen-presenting cells that initiate and regulate immune responses. They are unique in their feature to produce bioactive interleukin (IL)-12, a major proinflammatory cytokine connecting innate and adaptive immunity. Platelets  are highly reactive components of the circulatory system with fundamental importance in hemostasis and innate immunity. Immunomodulatory capacities of single specific human platelet-derived products on dendritics cells effector functions were identified.