I have recently worked on mutation in SARS-CoV-2 and I found some mutated clusters in Spike Glycoprotein, nsp1a and nsp7a. So, the virus may lead to change its receptor binding or even it's growth mechanism through non-structural mutation. Also, mutation is not equal all over the world, it's demographic.
So, I wanted to relate with all the respected researchers' knowledge about mutation to find any patterns in it.
Can the properties of second wave be determined in any analysis of genome change?
Here is the link to my work: Conference Paper New Computational Analysis to Identify the Mutational Change...
Mutations in SARS-CoV-2 viral genome and their implications
SARS-CoV-2 has its origin from bat coronavirus and after sufficient mutations to change in an intermediate host (probably pangolin) , it jumped to humans (1-2).
Initially it has been thought this SARS-CoV-2, the Coronavirus causing COVID-19 pandemic has a moderate degree of mutations, and a vaccine can be developed in such a situation(3). However, a recent study indicating multiple mutant strains, and sometimes multiple strains in a patient causing COVID-19 indicates its changing behaviour regarding transmission, immunity, and vaccine development (4).
1. Article The proximal origin of SARS-CoV-2
2. Article Probable Pangolin Origin of SARS-CoV-2 Associated with the C...
3. Article Moderate mutation rate in the SARS coronavirus genome and it...
4.. Preprint Spike mutation pipeline reveals the emergence of a more tran...
This link may be of some interest to you.: https://www.google.com/search?ei=0be0XpewMsWE9PwP3cuGKA&q=mutational+changes+in+cov19-2&oq=mutational+changes+in+cov19-2&gs_lcp=CgZwc3ktYWIQAzoCCAA6BAgAEEM6BggAEBYQHjoOCAAQ6gIQtAIQmgEQ5QI6BQgAEJECOgUIABCDAToECAAQCjoECAAQDToFCCEQoAE6BQghEKsCOgYIABANEB46CAgAEA0QChAeOggIABANEAUQHjoICAAQCBANEB46BggAEAcQHjoICAAQBxAFEB46BAgAEB46BggAEAUQHjoICCEQFhAdEB46BwghEAoQoAFQh-YkWP6NKWD2lyloAXAAeAOAAeECiAGMMJIBCTQwLjEyLjEuM5gBAKABAaoBB2d3cy13aXqwAQY&sclient=psy-ab&ved=0ahUKEwjX3PXOkKPpAhVFAp0JHd2lAQUQ4dUDCAw&uact=5
Best wishes, David Booth
I have attached some Link, hope it will help :
Article Emerging SARS-CoV-2 mutation hot spots include a novel RNA-d...
Article Emergence of genomic diversity and recurrent mutations in SARS-CoV-2
Article Emergence of genomic diversity and recurrent mutations in SARS-CoV-2
Depending on the mutations of SARS-CoV-2, two concepts of the virus causing COVID-19 have become famous:
1. L and S types of SARS-CoV-2: (Reference 1)
Described in China, L being more lethal and contagious compared to less lethal S type from where it originated.
2. A, B, and C types of SARS-CoV-2 : (Reference 2)
Type A is closest to bats and pangolins, considered as the root-cause of the COVID-19 outbreak. Two subclusters described, one linked to Wuhan, China and other linked to Australia and America.
Type B is a variant of the virus from Wuhan, China. Derived from type A by 2 mutations. It mutates slowly in China, but rapidly outside china.
Type C is the daughter of type B. One mutation different before it spread to Singapore and Europe.
References
1. Article The origin, transmission and clinical therapies on coronavir...
2. Article Phylogenetic network analysis of SARS-CoV-2 genomes
Muhammad Yousuf
Thank you for your valuable comments. It was really wonderful to read. Well recently we have found such significant strains in different demographics, one of them being very prevalent all across the world. Soon we hope to publish it. It very well shows points of coherence with the publications referred by you. Stay safe and healthy. Here I leave my recent paper, which also stated about a different mutated cluster being found in USA. Although this sample size was a bit early, hence later studies by us revealed the whole story. I hope it may come in some use.
Conference Paper New Computational Analysis to Identify the Mutational Change...
David Eugene Booth
Thank you very much sir for your regards. Yes, I read that and definitely it was interesting. More and more these results are getting published which may help us in a better way. Here I leave my recent paper, in the hope that it may interest you.
Conference Paper New Computational Analysis to Identify the Mutational Change...
Stay safe and healthy sir.
Tathagata Dey.
Asif Shahriar
Thank you sir for the suggestions. I read both of them, especially the publication on genome diversity was very interesting. Here is my recent paper, you may read.
Conference Paper New Computational Analysis to Identify the Mutational Change...
Stay safe and protected.
Talha Bin Emran
Thank you sir for your valuable suggestions. It was nice and informative paper, although I couldn't agree to utmost with the paper, however it was wonderful. Stay safe and healthy sir.
