How to detect spurious correlation in a statistical dataset with binary variables?

17 January 2021 7,892 25 View

Can somebody explain to me why RNA looks like this on RNA electrophoresis picture down below?

I extract the RNA from muscle tissue using Qiagen RNeasy Micro kit (50) (kat.74004). Everything fine with RNA concentration - about 300-500 ng/microliter. Before putting it into wells I mix my RNA...

19 November 2020 2,449 5 View

Can you help me figure out how many EDTA I need to add in the solution?

Composition 2X Loading dye for RNA electrophoresis 95% formamide 0.025% SDS 0.025% bromophenol blue 0.025% xylene cyanol FF 0.025% ethidium bromide 0.5 mM EDTA. I wanna to prepare 10 ml of the...

10 November 2020 4,759 3 View

RNN/LSTM Networks : How to take into account different values of times on different time-series?

LSTM tools of the Matlab allow us to perform classification of the time-series. It is assumed, that different time-series can have different length, but they should have same interval of...

13 October 2020 3,484 3 View

Deep Learning : How on one model to take into account both dynamic (time-series) and static features ?

Matlab tools for Deeep Learning allow us to solve classification tasks with static features (e.g., pixels values of images) and tasks with dynamic features (time-series). For time-series it is...

06 September 2020 9,942 6 View

How to apply Operational and Dynamic Routines to Organization Design?

Dear colleagues, I'm working on methodology of transforming existing organization for manufacturing companies. Could you please guide me on how to approach the following questions: 1. How to...

08 July 2020 1,754 7 View

How to perform the ordinary one-way ANOVA analysis to compare the pharmacological effects for different drug-like substances?

The one-way ANOVA analysis is important to find out whether measured pharmacological effects (the means and medians) observed for three or more drugs are distinct or they are due to a chance....

11 May 2020 4,605 6 View

How to evaluate two-dimensional probability based on two one-dimensional (marginal)?

23 April 2020 6,418 9 View

Does anybody have experimental data on ferroresonance phenomena?

Does anybody have a reliable experimental data on ferroresonance phenomena in a transformer (single- or three-phase)? Thanking you in anticipation, Sergey Zirka

17 April 2020 8,656 4 View

Are there any changes in the tensional behavior of single-wall carbon nanotubes (CNT) with different chiral indexes?

We simulated (LAMMPS program) the tensional behavior of CNTs with different chiral indexes (10, 10; 0, 10, and 10,0) using the original CH.airebo potentials (Stuart et al., 2000). The plot...

16 January 2020 8,147 3 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

Could any one guide me, to write research proposal for grant? ?

We have one plant, the local people using this for controlling blood sugar, the toxicity and antidiabetic activity of the plant is not reported yet, please guide from whag should be the process ?...

02 March 2021 2,300 1 View

How to empty large intestine in mice ?

Hi all I am working on colon-targeted drug delivery for which I kept mice fasting for 6h using fasting grills during scotophase (dark period). I observed liquid fecal content in the cecum and...

23 February 2021 7,701 2 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

I am looking for a simple software program to model 3D chemical bonds. The purpose is to generate high-quality graphical abstracts. Any suggestion?

Hello everyone: I am looking for a simple software program to model chemical bonds. The purpose is to generate a high-quality graphical abstract for a top leading journal in the field of...

23 February 2021 8,012 3 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

How to minimise the risk of being abused the profile of potential participants tagged in a social media post?

Dear colleagues, I got this one in one project I did ethics review. It's great to hear about your thoughts/experiences. "Doing an open recruitment online (i.e., via Facebook) requires public...

22 February 2021 3,322 3 View

Which alginate is best for making gel for wound dressing application?

We are looking into utilizing alginate as a gel coating on an HDPE substrate for drug delivery. I would like to ask the community about their experience with alginate and which commercial sources...

15 February 2021 4,319 4 View

Any natural extract (that is easily available) or any drug combination triple which i can use against gram negative?

I'm working on gram negative i want to use any natural extract (plant extract) or triple drug combination against its biofilm formation.

14 February 2021 1,403 3 View