Is there any mouse model of Alzheimer's disease that includes 5' UTR region of the APP gene?

06 June 2017 1 9K Report

Alzheimer's disease

It seems that the best mouse model of Alzheimer Dis. was the strain CVN-AD, described in the paper Kan et al., (J. Neuroscience, 15, 2015 • 35(15):5969 –5982. These mice had specific changes in amiloids as well in tau. Unfortunately I have no information on the genetic specificity.

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