If we want to use high dose per fraction (more than 6 Gy per fraction) then LQ model is not recommended to use in our clinics because it gives the overestimation of cell killing. So, is there any model except LQ-L which can be used in our routine clinical practice?
Hi,
I recommend this paper:
The tumor radiobiology of SRS and SBRT: Are more than the 5 Rs involved? by
Brown, J. Martin, Carlson, David J. and Brenner, David J. (International Journal of Radiation Oncology Biology Physics)
Perhaps the LQ model can be useful in extreme hypofractination more than we thought.
You may be interested in the following paper on LQ for SBRT of 395 patients with stage 1 non-small cell lung cancer https://pubmed.ncbi.nlm.nih.gov/24183066/
Linear quadratic model (LQ) and the universal survival curve (USC) model can be used for these techniques. But LQ model overestimates and USC model predicted much lower fractionation sensitivity. Literature shows that LQ-L model best fits for SRS and SBRT . You can go through this articleArticle Some implications of linear-quadratic-linear radiation dose-...
- Badges
- Science topic
- Similar topics
- Clinical Pharmacology
- Dosing