I am doing texture analysis of Non contrast CT images. I intend to find out what texture feature is best to discriminate between lesions and normal tissues.
Actually, there are many you can use (see, for instance: http://www.cs.bris.ac.uk/publications/Papers/2000853.pdf).
Among them, I would start with LBP (code available here: http://www.cse.oulu.fi/CMV/Downloads/LBPMatlab), which proved effective in many applications, and related methods (http://dismac.dii.unipg.it/hep/).
Gabor filters could be another option - which however requires a bit more of tuning. There's a good implementation here: http://www.it.lut.fi/project/simplegabor/).