Il-6/sIL-6r compound plays as pro-inflammatory while Il-10 plays as anti-inflammatory. But there's a connection between these two cytokines. Some evidence says that Il-6 increase IL-10 production and some others say sIL-6R has positive relation with IL-10.
But Il-6 has two different form of activation. One is associated with soluble receptor (pro-inflammatory) and another is with membrane bound receptor (anti-inflammatory).
I want to know is there any results which shows the difference between IL-10 expression induced by sil-6r and membrane bound il-6r and also about the role of corticosteroid in expressions? Can anyone help?
Thank you.
It's a clever and probably important question. I won't pretend to know an answer, but I'll say whatever it is that you're trying to do with this information, I'm excited about it. Good luck & I hope others will have something smarter to say.
Thanks John. Hope someone can help me to find the answer. I am also searching to find some clues about the answer.
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans.
Try this article. Looks promising. Let me know if it helps. Love immunobiology:)
Lots of thanks Katheleen. This article helps me to match the dots which I was looking for :)
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