Although it is often said that plant- or mushroom-extracted compounds display their antibacterial activity through a dose-dependent manner, sometimes I observe that it is not practically always the case. Sometimes, an extract show potent antibacterial activity at lower doses, while it is ineffective at high doses. Any suggestion or postulation is welcome!
Kindly check the following link in which the effects of different concentrations of Althaea officinalis extract, chlorhexidine (CHX), and penicillin on Streptococcus mutans and Lactobacillus acidophilus has been determined and compared:
Article Antibacterial Effects of Different Concentrations of Althaea...
Also, kindly check:
Article The antibacterial activity of extracts of nine plant species...
Article Antibacterial activities of the extracts, fractions and isol...
The active ingredient may not be soluble at higher concentrations. Precipitation can result in a lower concentration in solution than the solubility of the compound would predict. Also, if you are doing a broth microdilution assay, it is possible to mistake the turbidity of the precipitate for bacterial growth.
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