I am not aware of psychopharmacological interventions that may be useful; however, a referral to a therapist who is skilled in the use of client-centered modalities would likely be beneficial if your patient is willing to see a therapist. Irritability and anxiety - if the cause is not organic in nature - and, especially in the presence of depressive symptoms, can be reduced through the promotion of self-efficacy and goal orientation that is tailored to the specific drug trial.

Following your project out of interest and alignment to my clinical work.    

don't know of neuropharma options- however, recent research more guided by

approaching body as a system might offer helpful biological interventions -

reco perlmutter's book brain maker references studies of impact from gut biome

imbalances and localized inflammations- has the temerity as a neurologist to 

venture beyond professional borders - could be helpful to contact him re your

question

If Cycloserine can't be stopped and the depressive symptoms are severe I would recommend a psychofarmacologic treatment. The novel antidepressant vortioxetine could represent a good option as It helps depressive and anxiety symptoms and has no farmacologic interactions